Au FK, Le KTD, Qi RZ*. Detection and assay of microtubule nucleator γ-tubulin ring complex. Methods Mol Biol (in press)

Au FKC, Lui ESW, Qi RZ*. Protocol to measure inter-centrosome distance in adherent cells using epifluorescence microscopy. STAR Protoc. 3(1):101227.

Cao H, Zhou X, Chen Y, Ip FCF, Chen Y, Lai NCH, Lo RMN, Tong EPS, Mok VCT, Kwok TCY, Alzheimer’s Disease Neuroimaging Initiative, Fu AKY, Ip NY*.  Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer's Disease Risk. J Alzheimers Dis. 86(4):1861-187.

Duan Y, Ye T, Qu Z, Chen Y, Miranda A, Zhou X, Lok KC, Chen Y, Fu AKY, Gradinaru V, Ip NY*.  Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer's disease alleviates amyloid-related pathologies in mice. Nat Biomed Eng. 6(2):168-180.

Fan R, Lai KO*. Understanding how kinesin motor proteins regulate postsynaptic function in neuron. FEBS J. 289(8):2128-2144.

Gao AX, Xia TCX, Mak MSH, Zhu KY, Dong TTX, Tsim KWK*.  A Herbal Mixture of Sesami Semen Nigrum and Longan Arillus Induces Neurite Outgrowth in Cultured Neurons and Shows Anti-Depression in Chronic Mild Stress-Induced Rats. Evid Based Complement Alternat Med. 2022:8809546.

Gao AX, Xiao J, Xia TCX, Dong TTX, Tsim KWK*, The extract of peanut shell enhances neurite outgrowth of neuronal cells: Recycling of agricultural waste for development of nutraceutical products. J Funct Foods. 91:105023.

Guo MS, Gao X, Hu W, Wang X, Dong TT, Tsim KWK*. Scutellarin potentiates the skin regenerative function of self growth colony, an optimized platelet-rich plasma extract, in cultured keratinocytes through VEGF receptor and MAPK signaling. J Cosmet Dermatol. doi:10.1111/jocd.14800.

Guo MS, Wu Q, Dong TT, Tsim KWK*. The UV-induced uptake of melanosome by skin keratinocyte is triggered by α7 nicotinic acetylcholine receptor-mediated phagocytosis. FEBS J. doi: 10.1111/febs.16613.

Han L, Wang G, Zhou S, Situ C, He Z, Li Y, Qiu Y, Huang Y, Xu A, Ong MTY, Wang H, Zhang J, Wu Z*.  Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine. Cell Rep. 39(9):110884.

Hu WH, Zhang XY, Leung KW, Duan R, Dong TT, Qin QW, Tsim KW*. Resveratrol, an Inhibitor Binding to VEGF, Restores the Pathology of Abnormal Angiogenesis in Retinopathy of Prematurity (ROP) in Mice: Application by Intravitreal and Topical Instillation. Int J Mol Sci. 23(12):6455.

Jiang Y, Zhou X, Wong HY, Ouyang L, Ip FCF, Chau VM, Lau SF, Wu W, Wong DYK, Seo H, Fu WY, Lai NCH, Chen Y, Chen Y, Tong EP, Alzheimer’s Disease Neuroimaging Initiative, Mok VC, Kwok TC, Mok KY, Shoai M, Lehallier B, Losada PM, O’Brien E, Porter T, Laws SM, Hardy J, Wyss-Coray T, Masters CL, Fu AK, Ip NY*.  An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer's disease. Nat Aging. 2:616–634

Lam YS, Liu XX, Ke Y, Yung WH*. Edge-based network analysis reveals frequency specific network dynamics in aberrant anxiogenic processing in rats. Network Neuroscience. 6(3):816–833.

Lin S, Wang X, Tang RW, Lee HC, Chan HH, Choi SSA, Dong TT, Leung KW, Webb SE, Miller AL, Tsim KW*. The Extracts of Polygonum cuspidatum Root and Rhizome Block the Entry of SARS-CoV-2 Wild-Type and Omicron Pseudotyped Viruses via Inhibition of the S-Protein and 3CL Protease. Molecules. 27(12):3806.

Lou L, Yu T, Dai Y, Zhao S, Feng S, Xu J, Wen Z*.  Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression. Proc Natl Acad Sci U S A. 119(39):e2203273119.

Qin Z, She Z, Chen C, Wu W, Lau JKY, Ip NY, Qu JY*. Deep tissue multi-photon imaging using adaptive optics with direct focus sensing and shaping. Nat Biotechnol. doi:10.1038/s41587-022-01343-w

Sun W, Tang P, Liang Y, Li J, Feng J, Zhang N, Lu D, He J*, Chen X. The anterior cingulate cortex directly enhances auditory cortical responses in air-puffing-facilitated flight behavior. Cell Rep. 38(10):110506.

Wang X, Lin S, Tang RW, Lee HC, Chan HH, Choi SSA, Leung KW, Webb SE, Miller AL, Tsim KW*. Polygoni multiflori radix extracts inhibit SARS-CoV-2 pseudovirus entry in HEK293T cells and zebrafish larvae. Phytomedicine. 102:154154.

Wong HY, Zhong H, Zhong M, Zhou X, Chan PYC, Kwok TCY, Mok K, Hardy J, Ip FCF, Fu AKY, Ip NY*.  Demographics and Medication Use of Patients with Late-Onset Alzheimer’s Disease in Hong Kong. J Alzheimer's Dis. 87:1205–1213.

Wu J, Peng Z, Wu Q, Tang RWL, Dong T, Wang H, Tsim KWK*. The water extract of Aloe vera prevents fluoxetine-induced multiple-drug resistance of E. coli by inhibiting reactive oxygen species formation and membrane permeability. Phytomedicine. 106:154421.

Wu Q, Bai P, Guo H, Guo MSS, Xia Y, Xia Y, Gao X, Wang X, Wu J, Dong TTX, Tsim KWK*. Capsaicin, a Phytochemical From Chili Pepper, Alleviates the Ultraviolet Irradiation-Induced Decline of Collagen in Dermal Fibroblast via Blocking the Generation of Reactive Oxygen Species. Front Pharmacol. 13:872912.

Wu W, He S, Wu J, Chen C, Li X, Liu K, Qu JY*.  Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window. Nat Commun. 13(1):1959.

Xia YT, Wu QY, Cheng EHC, Dong TTX, Qin QW, Wang WX, Tsim KWK*. The inclusion of extract from aerial part of Scutellaria baicalensis in feeding of pearl gentian grouper (Epinephelus fuscoguttatus♀ × Epinephelus lanceo-latus♂) promotes growth and immunity. Fish Shellfish Immunol. 127:521-529.

Xia Y, Wu Q, Mak S, Liu EYL, Zheng BZY, Dong TTX, Pi R, Tsim KWK*. Regulation of acetylcholinesterase during the lipopolysaccharide-induced inflammatory responses in microglial cells. FASEB J. 36(3):e22189.

Yuen GK, Ho BS, Lin LS, Dong TT, Tsim KW*. Tectoridin Stimulates the Activity of Human Dermal Papilla Cells and Promotes Hair Shaft Elongation in Mouse Vibrissae Hair Follicle Culture. Molecules. 27(2):400.

Zeng W, Yue L, Lam KSW, Zhang W, So WK, Tse EHY, Cheung TH*. CPEB1 directs muscle stem cell activation by reprogramming the translational landscape. Nat Commun. 13(1):947.

Zhao S, Feng S, Tian Y, Wen Z*. Hemogenic and aortic endothelium arise from a common hemogenic angioblast precursor and are specified by the Etv2 dosage. Proc Natl Acad Sci U S A. 119(13):e2119051119.

Zhou S, Han L, Wu Z*. A Long Journey before Cycling: Regulation of Quiescence Exit in Adult Muscle Satellite Cells. Int J Mol Sci. 23(3):1748.



Chan GKL, Guo MS, Dai DK, Lai QWS, Fung KWC, Zheng BZ, Wu KQ, Man BKK, Dong TT, Tsim KWK*. An Optimized Extract, Named Self-Growth Colony, from Platelet-Rich Plasma Shows Robust Skin Rejuvenation and Anti-Ageing Properties: A Novel Technology in Development of Cosmetics. Skin Pharmacol Physiol. 34(2):74-85.

Chen C, Qin Z, He S, Liu S, Lau SF, Wu W, Zhu D, Ip NY, Qu JY*.  High-resolution two-photon transcranial imaging of brain using direct wavefront sensing. Photonics Res. 9(6):1144-1156.

Chen C, She Z, Tang P, Qin Z, He J, Qu JY*  Study of neurovascular coupling by using mesoscopic and microscopic imaging. iScience. 24(10):103176.

Chung YK, Wong YH*. Re-examining the 'Dissociation Model' of G protein activation from the perspective of Gβγ signaling. FEBS J. 288(8):2490-2501.

Dong A, Cheung TH*. Deciphering the chromatin organization and dynamics for muscle stem cell function. Curr Opin Cell Biol. 73:124-132.

Dong R, Li X, Lai KO*. Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons. Life (Basel). 11(11):1132.

Feng H, Su J, Fang W, Chen X, He J*. The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the mouse lateral amygdala via cholecystokinin. elife. 10:e69333.

Fu WY, Hung KW, Lau SF, Butt B, Yuen VW, Fu G, Chan IC, Ip FCF, Fu AKY, Ip NY*. Rhynchophylline Administration Ameliorates Amyloid-β Pathology and Inflammation in an Alzheimer's Disease Transgenic Mouse Model. ACS Chem Neurosci. 12(22):4249-4256.

Gong G, Yu H, Zheng Y*, Qi B, He H, Yin T, Dong TT, Tsim KW*.  Astragaloside IV, a saponin from Astragalus membranaceus var. mongholicus, induces expressions of heme recycle proteins via signaling of Nrf2/ARE in cultured macrophages. J Ethnopharmacol. 265:113389.

Guo MS, Wu Q, Lai QWS, Wang X, Bai P, Fung KWC, Dong TT, Tsim KWK*. A prepared platelet-rich plasma extract, namely Self-Growth Colony, inhibits melanogenesis by down-regulating microphthalmia-associated transcription factor in skin melanocyte. J Cosmet Dermatol. 20(10):3278-3288.

He X, Urip BA, Zhang Z, Ngan CC, Feng B*. Evolving AAV-delivered therapeutics towards ultimate cures. J Mol Med (Berl). 99(5):593-617.

Hu WH, Dai DK, Zheng BZ, Duan R, Chan GK, Dong TT, Qin QW, Tsim KW*.  The binding of kaempferol-3-O-rutinoside to vascular endothelial growth factor potentiates anti-inflammatory efficiencies in lipopolysaccharide-treated mouse macrophage RAW264.7 cells. Phytomedicine. 80:153400.

Ip FCF, Fu G, Yang F, Kang F, Sun P, Ling CY, Cheung K, Xie F, Hu Y, Fu L*, Ip NY*.  A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice. Eur J Med Chem. 226:113827.

Jiang Y, Zhou X, Ip FC, Chan P, Chen Y, Lai NCH, Cheung K, Lo RMN, Tong EPS, Wong BWY, Chan ALT, Mok VCT, Kwok TCY, Mok KY, Hardy J, Zetterberg H, Fu AKY, Ip NY*.  Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and staging. Alzheimers Dement. 18(1):88-102.

Konovalov KA, Wang W, Wang G, Goonetilleke EC, Gao X, Wang D, Huang X*.  A comprehensive mechanism for 5-carboxylcytosine-induced transcriptional pausing revealed by Markov state models. J Biol Chem. 296:100735.

Kwan KKL, Yun H, Dong TTX, Tsim KWK*. Ginsenosides attenuate bioenergetics and morphology of mitochondria in cultured PC12 cells under the insult of amyloid beta-peptide. J Ginseng Res. 45(4):473-481.

Kwan KKL, Wong, TY, Yu AXD, Dong TTX, Lam HHL, Tsim KWK*. The Osteogenic Function of Danggui Buxue Tang, a Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, Is Optimized by Boiling the Two Herbs Together: Signaling Analyses Revealed by Systems Biology. Processes.  9(7):1119.

Kwan KKL, Dong TTX, Tsim KWK*. Danggui Buxue Tang, a Chinese herbal decoction containing Astragali Radix and Angelicae Sinensis Radix, improves mitochrondial bioenergetics in osteoblast. Phytomedicine. 88:153605.

Kwan KKL, Wong TY, Yu AXD, Dong TTX, Lam HHN, Tsim KWK*. Integrated Omics Reveals the Orchestrating Role of Calycosin in Danggui Buxue Tang, a Herbal Formula Containing Angelicae Sinensis Radix and Astragali Radix, in Inducing Osteoblastic Differentiation and Proliferation. Front Pharmacol. 12:670947.

Lai QWS, Guo MSS, Wu KQ, Liao Z, Guan D, Dong TT, Tong P, Tsim KWK*. Edible Bird's Nest, an Asian Health Food Supplement, Possesses Moisturizing Effect by Regulating Expression of Filaggrin in Skin Keratinocyte. Front Pharmacol. 12:685982.

Lau J, Tian M, Shen Y, Lau SF, Fu WY, Fu AK, Ip NY*. Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model. Sci Rep. 11(1):4359.

Lau SF, Fu AKY, Ip NY*. Cytokine signaling convergence regulates the microglial state transition in Alzheimer's disease. Cell Mol Life Sci. 78(10):4703-4712.

Lau SF, Wu W, Seo H, Fu AKY, Ip NY*. Quantitative in vivo assessment of amyloid-beta phagocytic capacity in an Alzheimer's disease mouse model. STAR Protoc. 2(1):100265.

Li C, Liu Z, Goonetilleke EC, Huang X*. Temperature-dependent kinetic pathways of heterogeneous ice nucleation competing between classical and non-classical nucleation. Nat Commun. 12(1):4954.

Liao C, Xu J, Chen Y*, Ip NY*. Retinal Dysfunction in Alzheimer's Disease and Implications for Biomarkers. Biomolecules. 11(8):1215.

Liu EYL, Mak S, Kong X, Xia Y, Kwan KKL, Xu ML, Tsim KWK*.  Tacrine Induces Endoplasmic Reticulum-Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells. Mol Pharmacol. 100(5):456-469.

Tse LH, Wong YH*. Modeling the Heterodimer Interfaces of Melatonin Receptors. Front Cell Neurosci. 15:725296.

Unarta IC, Cao S, Kubo S, Wang W, Cheung PP, Gao X, Takada S, Huang X*.  Role of bacterial RNA polymerase gate opening dynamics in DNA loading and antibiotics inhibition elucidated by quasi-Markov State Model. Proc Natl Acad Sci U S A. 118(17):e2024324118.

Unarta IC, Xu J, Shang Y, Cheung CHP, Zhu R, Chen X, Cao S, Cheung PP, Bierer D, Zhang M*, Huang X*, Li X*.  Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain. RSC Chem Biol. 2(4):1274-1284.

Urbán N*, Cheung TH*.  Stem cell quiescence: the challenging path to activation. Development. 148(3):dev165084.

Wang X, Unarta IC, Cheung PP, Huang X*. Elucidating molecular mechanisms of functional conformational changes of proteins via Markov state models. Curr Opin Struct Biol. 67:69-77.

Wang X, Ye F, Wen Z, Guo Z, Yu C, Huang WK, Rojas Ringeling F, Su Y, Zheng W, Zhou G, Christian KM, Song H*, Zhang M*, Ming GL*.  Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders. Mol Psychiatry. 26(4):1346-1360.

Wang Y, Chong TH, Unarta IC, Xu X, Suarez GD, Wang J, Lis JT, Huang X, Cheung PP*.  EmPC-seq: Accurate RNA-sequencing and Bioinformatics Platform to Map RNA Polymerases and Remove Background Error. Bio Protoc.11(4):e3921.

Wang Y, Fu AKY, Ip NY*. IL-33/ST2 Signaling Regulates Synaptic Plasticity and Homeostasis in the Adult Hippocampal Circuitry. DNA Cell Biol. 40(9):1125-1130.

Wang Y, Fu AKY, Ip NY* Instructive roles of astrocytes in hippocampal synaptic plasticity: neuronal activity-dependent regulatory mechanisms. FEBS J. 289(8):2202-2218.

Wang Y, Fu WY, Cheung K, Hung KW, Chen C, Geng H, Yung WH, Qu J, Fu AK, Ip NY*.  Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus. Proc Natl Acad Sci U S A. 118(1):e2020810118.

Wong KM, Song J, Wong YH*. CTCF and EGR1 suppress breast cancer cell migration through transcriptional control of Nm23-H1. Sci Rep. 11(1):491.

Wu W, Li X, Qu JY, He S*. In vivo Imaging of Biological Tissues with Combined Two-Photon Fluorescence and Stimulated Raman Scattering Microscopy. J Vis Exp. (178). doi:10.3791/63411.

Xia Y, Cheng HC, Xia Y, Wu Q, Zhang HL, Lin S, Dong TT, Qin QW, Wang W, Tsim KW*. Characterization of a macrophagic-like cell line derived from rabbit fish (Siganus fuscescens): An illustration of anti-inflammatory responses of the herbal extract of Scutellaria baicalensis. Fish Shellfish Immunol Rep. 2:100036.

Xia YT, Cheng EH, Zheng BZ, Wu QY, Dong TT, Duan R, Qin QW, Wang WX, Tsim KW*. Feeding containing the aerial part of Scutellaria baicalensis promotes the growth and nutritive value of rabbit fish Siganus fuscescens. Food Sci Nutr. 9(9):4827-4838.

Xiong Gao A, Xia TC, Shing-Hung Mak M, Kin-Leung Kwan K, Zhong-Yu Zheng B, Xiao J, Dong TT, Tsim KW*. Luteolin stimulates the NGF-induced neurite outgrowth in cultured PC12 cells through binding with NGF and potentiating its receptor signaling. Food Funct. 12(22):11515-11525.

Xu P*, Chang JC, Zhou X, Wang W, Bamkole M, Wong E, Bettayeb K, Jiang LL, Huang T, Luo W, Xu H, Nairn AC, Flajolet M, Ip NY, Li YM*, Greengard P.  GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease. J Exp Med. 218(8):e20202446.

Xu X, Zhang L, Chu JTS, Wang Y, Chin AWH, Chong TH, Dai Z, Poon LLM, Cheung PP, Huang X*.  A novel mechanism of enhanced transcription activity and fidelity for influenza A viral RNA-dependent RNA polymerase. Nucleic Acids Res. 49(15):8796-8810.

Ye T, Duan Y, Tsang HWS, Xu H, Chen Y, Cao H, Chen Y, Fu AKY, Ip NY*. Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases. Commun Biol. 4(1):195.

Yin C, Lui ESW, Jiang T, Qi RZ*. Proteolysis of γ-tubulin small complex proteins is mediated by the ubiquitin-proteasome system. FEBS Lett. doi:10.1002/1873-3468.14146.

Yu AX, Xiao J, Zhao SZ, Kong XP, Kwan KK, Zheng BZ, Wu KQ, Dong TT, Tsim KW*. Biological Evaluation and Transcriptomic Analysis of Corylin as an Inhibitor of Osteoclast Differentiation. Int J Mol Sci. 22(7):3540.

Zhang L*, Zhang D, Wang X, Yuan C, Li Y, Jia X, Gao X, Yen HL, Cheung PP*, Huang X*.  1'-Ribose cyano substitution allows Remdesivir to effectively inhibit nucleotide addition and proofreading during SARS-CoV-2 viral RNA replication. Phys Chem Chem Phys. 23(10):5852-5863.

Zhou S, Han L, Weng M, Zhu H, Heng Y, Wang G, Shen Z, Chen X, Fu X, Zhang M, Wu Z*. Paxbp1 controls a key checkpoint for cell growth and survival during early activation of quiescent muscle satellite cells. Proc Natl Acad Sci U S A. 118(13):e2021093118.

Zhou X, Chen C, Ip FC, Jiang Y, Cao H, Zhong H, Chen J, Ye T, Chen Y, Zhang Y, Ma S, Lo RM, Tong EP, Alzheimer’s Disease Neuroimaging Initiative, Mok VC, Kwok TC, Guo Q, Mok KY, Shoai M, Hardy J, Chen L, Fu AK, Ip NY*.  Deep learning methods improve polygenic risk analysis and prediction for Alzheimer’s disease. Res Sq. 1–30. doi:10.21203/

Zhou X, Fu AK, Ip NY*. APOE signaling in neurodegenerative diseases: an integrative approach targeting APOE coding and noncoding variants for disease intervention. Curr Opin Neurobiol. 69:58-67.



Au FKC, Hau BKT, Qi RZ*. Nek2-mediated GAS2L1 phosphorylation and centrosome-linker disassembly induce centrosome disjunction. J Cell Biol. 219(5):e201909094.

Chan KH, Tse LH, Huang X, Wong YH*. Molecular basis defining the selectivity of substituted isoquinolinones for the melatonin MT2 receptor. Biochem Pharmacol. 177:114020.

Chen J*, Tsim KWK.  A Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence. Front Pharmacol. 11:593655.

Cheung PP, Jiang B, Booth GT, Chong TH, Unarta IC, Wang Y, Suarez GD, Wang J*, Lis JT*, Huang X*.  Identifying Transcription Error-Enriched Genomic Loci Using Nuclear Run-on Circular-Sequencing Coupled with Background Error Modeling. J Mol Biol. 432(13):3933-3949.

Dong A, Preusch CB, So WK, Lin K, Luan S, Yi R, Wong JW, Wu Z, Cheung TH*. A long noncoding RNA, LncMyoD, modulates chromatin accessibility to regulate muscle stem cell myogenic lineage progression. Proc Natl Acad Sci U S A.117(51):32464-32475.

Gong G, Xie F, Zheng Y*, Hu W, Qi B, He H, Dong TT, Tsim KW.  The effect of methanol extract from Saussurea involucrata in the lipopolysaccharide-stimulated inflammation in cultured RAW 264.7 cells. J Ethnopharmacol. 251:112532.

Guo R, Guo S, Gao X, Wang H, Hu W, Duan R, Dong TTX, Tsim KWK*.  Fermentation of Danggui Buxue Tang, an ancient Chinese herbal mixture, together with Lactobacillus plantarum enhances the anti-diabetic functions of herbal product. Chin Med. 15:98.

He S, Tian Y, Feng S, Wu Y, Shen X, Chen K, He Y, Sun Q, Li X, Xu J*, Wen Z*, Qu JY*.  In vivo single-cell lineage tracing in zebrafish using high-resolution infrared laser-mediated gene induction microscopy. eLife. 9:e52024.

He S, Wei X, Qin Z, Chen C, Wu Z*, Qu JY* In vivo study of metabolic dynamics and heterogeneity in brown and beige fat by label-free multiphoton redox and fluorescence lifetime microscopy. J Biophotonics. 13(2):e201960057.

He S, Xu J, Qu JY*, Wen Z*.  Lightening the way of hematopoiesis: Infrared laser-mediated lineage tracing with high spatial-temporal resolution. Exp Hematol. 85:3-7.

Hu WH, Dai DK, Zheng BZ, Duan R, Dong TT, Qin QW, Tsim KW*.  Piceatannol, a Natural Analog of Resveratrol, Exerts Anti-angiogenic Efficiencies by Blockage of Vascular Endothelial Growth Factor Binding to Its Receptor. Molecules. 25(17):3769.

Hu WH, Mak SH, Zheng ZY, Xia YJ, Xu ML, Duan R, Dong TT, Li SP, Zhan CS, Shang XH, Tsim KW*.  Shexiang Baoxin Pill, a Traditional Chinese Herbal Formula, Rescues the Cognitive Impairments in APP/PS1 Transgenic Mice. Front Pharmacol.11:1045.

Hu WH, Wang HY, Xia YT, Dai DK, Xiong QP, Dong TT, Duan R, Chan GK, Qin QW, Tsim KW*.  Kaempferol, a Major Flavonoid in Ginkgo Folium, Potentiates Angiogenic Functions in Cultured Endothelial Cells by Binding to Vascular Endothelial Growth Factor. Front Pharmacol. 11:526.

Huang Y, Yao P, Leung KW, Wang H, Kong XP, Dong TTX, Chen Y, Qin QW, Tsim KWK*.  The Chinese medicinal herbs of spleen-meridian property regulate body temperature in yeast-induced fever rats. Phytomedicine. 74:152815.

Kong X, Chen Z, Xia Y, Liu EYL, Ren H, Wang C, Hu WWH, Dong TTX, Pi R, Tsim KWK*.  Dehydrocorydaline Accounts the Majority of Anti-Inflammatory Property of Corydalis Rhizoma in Cultured Macrophage. Evid Based Complement Alternat Med. 2020:4181696.

Kong XP, Ren HQ, Liu EYL, Leung KW, Guo SC, Duan R, Dong TTX, Tsim KWK*.  The Cholinesterase Inhibitory Properties of Stephaniae Tetrandrae Radix. Molecules. 25(24):5914.

Lau SF, Cao H, Fu AK, Ip NY*. Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease. Proc Natl Acad Sci U S A.117(41):25800-25809.

Lau SF, Chen C, Fu WY, Qu JY, Cheung TH, Fu AKY, Ip NY. IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer's Disease. Cell Rep. 31(3):107530.

Li Y, Liu W, Saini V, Wong YH*. Mutations at the dimer interface and surface residues of Nm23-H1 metastasis suppressor affect its expression and function. Mol Cell Biochem. 474(1-2):95-112.

Lin L, Lyu Q, Kwan PY, Zhao J, Fan R, Chai A, Lai CSW, Chan YS, Shen X, Lai KO*. The epilepsy and intellectual disability-associated protein TBC1D24 regulates the maintenance of excitatory synapses and animal behaviors. PLoS Genet. 16(1):e1008587.

Liu EY, Zheng ZX, Zheng BZ, Xia Y, Guo MS, Dong TT, Tsim KWK*.  Tectorigenin, an isoflavone aglycone from the rhizome of Belamcanda chinensis, induces neuronal expression of erythropoietin via accumulation of hypoxia-inducible factor-1α. Phytother Res. 34(6):1329-1337.

Liu EYL, Xia Y, Kong X, Guo MSS, Yu AXD, Zheng BZY, Mak S, Xu ML, Tsim KWK*.  Interacting with α 7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages. Acta Pharm Sin B. 10(10):1926-1942.

Liu Z, Yang Y, Gu A, Xu J, Mao Y, Lu H, Hu W, Lei QY, Li Z, Zhang M, Cai Y*, Wen W*.  Par complex cluster formation mediated by phase separation. Nat Commun. 11(1):2266.

Lo LH, Dong R, Lyu Q, Lai KO*. The protein arginine methyltransferase PRMT8 and substrate G3BP1 control Rac1-PAK1 signaling and actin cytoskeleton for dendritic spine maturation. Cell Rep. 31(10):107744.

Lo LH, Lai KO*. Dysregulation of protein synthesis and dendritic spine morphogenesis in ASD: studies in human pluripotent stem cells. Mol Autism. 11(1):40.

Luo W, Ip FC, Fu G, Cheung K, Tian Y, Hu Y, Sinha A, Cheng E, Wu X, Bustos V, Greengard P, Li Y, Sinha SC*, Ip NY*.  A pentacyclic triterpene from Ligustrum lucidum targets γ-secretase. ACS Chem Neurosci. 11(18):2827-2835.

Mu MD, Qian ZM, Yang SX, Rong KL, Yung WH*, Ke Y*Therapeutic effect of a histone demethylase inhibitor in Parkinson's disease. Cell Death Dis. 11(10):927.

Ouyang L, Chen Y, Wang Y, Chen Y, Fu AK, Fu WY, Ip NY*. p39-associated Cdk5 activity regulates dendritic morphogenesis. Sci Rep. 10(1):18746.

Pan C, Liu C, Peng J, Ren P, Huang X*.  Three‐site and five‐site fixed‐charge water models compatible with AMOEBA force field. J Comput Chem. 41:1034–1044.

Peng S, Wang X, Zhang L*, He S, Zhao XS*, Huang X*, Chen C*.  Target search and recognition mechanisms of glycosylase AlkD revealed by scanning FRET-FCS and Markov state models. Proc Natl Acad Sci U S A. 117(36):21889-21895.

Qin Z, Chen C, He S, Wang Y, Tam KF, Ip NY*, Qu JY*. Adaptive optics two-photon endomicroscopy enables deep-brain imaging at synaptic resolution over large volumes. Sci Adv. 6(40):eabc6521.

Qin Z, He S, Yang C, Yung JS, Chen C, Leung CK, Liu K, Qu JY*.  Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo. Light Sci Appl. 9:79.

Wang J, Zhang C, Feng B*. The rapidly advancing Class 2 CRISPR-Cas technologies: A customizable toolbox for molecular manipulations. J Cell Mol Med. 24(6):3256–3270.

Wu Q, Bai P, Xia Y, Lai QWS, Guo MSS, Dai K, Zheng Z, Ling CSJ, Dong TTX, Pi R, Tsim KWK*.  Solar light induces expression of acetylcholinesterase in skin keratinocytes: Signalling mediated by activator protein 1 transcription factor. Neurochem Int. 141:104861.

Wu Q, Bai P, Xia Y, Xia Y, Xu B, Dai K, Zheng Z, Guo MSS, Fung KWC, Dong TTX, Tsim KWK*. Capsaicin Inhibits the Expression of Melanogenic Proteins in Melanocyte via Activation of TRPV1 Channel: Identifying an Inhibitor of Skin Melanogenesis. J Agric Food Chem. 68(50):14863-14873.

Wu Q, Xia Y, Dai K, Bai P, Kwan KKL, Guo MSS, Dong TTX, Tsim KWK*. Solar light induces the release of acetylcholine from skin keratinocytes affecting melanogenesis. FASEB J. 34(7):8941-8958.

Wu S, Nguyen LTM, Pan H, Hassan S, Dai Y, Xu J, Wen Z*.  Two phenotypically and functionally distinct microglial populations in adult zebrafish. Sci Adv. 6(47):eabd1160.

Xia YT, Chan GKL, Wang HY, Dong TTX, Duan R, Hu WH, Qin QW, Wang WX, Tsim KWK*.  The anti-bacterial effects of aerial parts of Scutellaria baicalensis: Potential application as an additive in aquaculture feedings. Aquaculture. 526:735418.

Xia YT, Hu WH, Wu QY, Dong TT, Duan R, Xiao J, Li SP, Qin QW, Wang WX, Tsim KW*.  The herbal extract deriving from aerial parts of Scutellaria baicalensis shows anti-inflammation and anti-hypoxia responses in cultured fin cells from rabbit fish. Fish Shellfish Immunol. 106:71-78.

Yip JLK, Lee MMK, Leung CCY, Tse MK, Cheung AST, Wong YH*. AGS3 and Gαi3 Are Concomitantly Upregulated as Part of the Spindle Orientation Complex during Differentiation of Human Neural Progenitor Cells. Molecules. 25(21):5169.

Yu AX, Xu ML, Yao P, Kwan KK, Liu YX, Duan R, Dong TT, Ko RK, Tsim KW*. Corylin, a flavonoid derived from Psoralea Fructus, induces osteoblastic differentiation via estrogen and Wnt/β-catenin signaling pathways. FASEB J. 34(3):4311-4328.

Yu T, Kuang H, Chen J, Lin X, Wu Y, Chen K, Zhang M, Zhang W*, Wen Z*.  Tripartite-motif family protein 35-28 regulates microglia development by preventing necrotic death of microglial precursors in zebrafish. J Biol Chem. 295(26):8846-8856.

Yue L, Cheung TH*. Protocol for Isolation and Characterization of In Situ Fixed Quiescent Muscle Stem Cells. STAR Protoc. 1(3):100128.

Yue L, Wan R, Luan S, Zeng W, Cheung TH*. Dek Modulates Global Intron Retention during Muscle Stem Cells Quiescence Exit. Dev Cell. 53(6):661-676.e6.

Zhang Z, Zheng X, Sun W, Peng Y, Guo Y, Lu D, Zheng Y, Li X, Jendrichovsky P, Tang P, He L, Li M, Liu Q, Xu F, Ng G, Chen X, He J*.  Visuoauditory Associative Memory Established with Cholecystokinin Under Anesthesia Is Retrieved in Behavioral Contexts. J Neurosci. 40(10):2025-2037.

Zhao J, Fok AHK, Fan R, Kwan PY, Chan HL, Lo LHY, Chan YS, Yung WH, Huang J, Lai CSW*, Lai KO*.  Specific depletion of the motor protein KIF5B leads to deficits in dendritic transport, synaptic plasticity and memory. eLife. 9:e53456.

Zheng Y, Xin G, Gong G, Dong TT, Li P, Tsim KWK*.  Evaluation of Anti-Inflammatory Components of Guizhi Fuling Capsule, an Ancient Chinese Herbal Formula, in Human Umbilical Vein Endothelial Cells. Evid Based Complement Alternat Med. 2020:2029134.

Zhou X, Chen Y, Ip FC, Lai NC, Li YY, Jiang Y, Zhong H, Chen Y, Zhang Y, Ma S, Lo RM, Cheung K, Tong EP, Ko H, Shoai M, Mok KY, Hardy J, Mok VC, Kwok TC, Fu AK, Ip NY*.  Genetic and polygenic risk score analysis for Alzheimer’s disease in the Chinese population. Alzheimers Dement (Amst). 12(1):e12074.



Chen WW, Fu WY, Su YT, Fang WQ, Fu AKY, Ip NY*. Increased Axin expression enhances adult hippocampal neurogenesis and exerts an antidepressant effect. Sci Rep. 9(1):1190.

Chen Y*, Fu AKY, Ip NY*. Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies. Pharmacol Ther. 195:186-198.

Chen Y*, Xu J, Zhou X, Liu S, Zhang Y, Ma S, Fu AKY, Ip NY, Chen Y*. Changes of protein phosphorylation are associated with synaptic functions during the early stage of Alzheimer's Disease. ACS Chem Neurosci. 10(9):3986-3996.

Fu WY, Wang X, Ip NY*. Targeting Neuroinflammation as a Therapeutic Strategy for Alzheimer's Disease: Mechanisms, Drug Candidates, and New Opportunities. ACS Chem Neurosci. 10(2):872-879.

Hu WH, Chan GK, Duan R, Wang HY, Kong XP, Dong TT, Tsim KW*. Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer. Cancers (Basel). 11(12):1828.

Hu WH, Duan R, Xia YT, Xiong QP, Wang HY, Chan GK, Liu SY, Dong TT, Qin QW, Tsim KW*.  Binding of Resveratrol to Vascular Endothelial Growth Factor Suppresses Angiogenesis by Inhibiting the Receptor Signaling. J Agric Food Chem. 67(4):1127-1137.

Hu WH, Wang HY, Kong XP, Xiong QP, Poon KK, Xu L, Duan R, Chan GK, Dong TT, Tsim KW*.  Polydatin suppresses VEGF-induced angiogenesis through binding with VEGF and inhibiting its receptor signaling. FASEB J. 33(1):532-544.

Huang Y, Kwan KKL, Leung KW, Yao P, Wang H, Dong TT, Tsim KWK*. Ginseng extracts modulate mitochondrial bioenergetics of live cardiomyoblasts: a functional comparison of different extraction solvents. J Ginseng Res. 43(4):517-526.

Jin Y, Wang CY, Hu WH, Huang Y, Xu ML, Wang HY, Kong XP, Chen YC, Dong TT, Qin QW, Tsim KWK*.  An optimization of ultra-sonication-assisted extraction from flowers of Apocynum venetum in targeting to amount of free amino acids determined by UPLC-MS/MS. Food Qual Saf. 3(1):52-60.

Kong XP, Liu EYL, Chen ZC, Xu ML, Yu AXD, Wu QY, Xia YJ, Duan R, Dong TTX*, Tsim KWK*.  Synergistic inhibition of acetylcholinesterase by alkaloids derived from Stephaniae Tetrandrae Radix, Coptidis Rhizoma and Phellodendri Chinensis Cortex. Molecules. 24(24):4567.

Kwan KKL, Huang Y, Leung KW, Dong TTX, Tsim KWK*. Danggui Buxue Tang, a Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, Modulates Mitochondrial Bioenergetics in Cultured Cardiomyoblasts. Front Pharmacol. 10:614.

Lam KYC, Wu QY, Hu WH, Yao P, Wang HY, Dong TTX, Tsim KWK*. Asarones from Acori Tatarinowii Rhizoma stimulate expression and secretion of neurotrophic factors in cultured astrocytes. Neurosci Lett. 707:134308.

Lei J, Sheng G, Cheung PP, Wang S, Li Y, Gao X, Zhang Y*, Wang Y*, Huang X*.  Two symmetric arginine residues play distinct roles in Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc Natl Acad Sci U S A. 116(3):845-853.

Liu EYL, Xu ML, Xia Y, Kong X, Wu Q, Dong TTX, Tsim KWK*. Activation of G protein-coupled receptor 30 by flavonoids leads to expression of acetylcholinesterase in cultured PC12 cells. Chem Biol Interact. 306:147-151.

Shen Y, Wang K, Qi RZ*. The catalytic subunit of DNA polymerase δ is a nucleocytoplasmic shuttling protein. Exp Cell Res. 375(2):36-40.

Su YT, Lau SF, Ip JPK, Cheung K, Cheung THT, Fu AKY, Ip NY*. α2-Chimaerin is essential for neural stem cell homeostasis in mouse adult neurogenesis. Proc Natl Acad Sci U S A. 116(27):13651-13660.

Tse CKM, Xu J, Xu L, Sheong FK, Wang S, Chow HY, Gao X, Li X, Cheung PP*, Wang D*, Zhang Y*, Huang X*.  Intrinsic Cleavage of RNA Polymerase II Adopts a Nucleobase-independent Mechanism Assisted by Transcript Phosphate. Nat Energy. 2(3):228-235.

Tse LH, Wong YH*. GPCRs in Autocrine and Paracrine Regulations. Front Endocrinol (Lausanne). 10:428.

van de Willige D, Hummel JJ, Alkemade C, Kahn OI, Au FK, Qi RZ, Dogterom M, Koenderink GH*, Hoogenraad CC*, Akhmanova A*.  Cytolinker Gas2L1 regulates axon morphology through microtubule-modulated actin stabilization. EMBO Rep. 20(11):e47732.

Wang HY, Guo LX, Hu WH, Peng ZT, Wang C, Chen ZC, Liu EYL, Dong TTX, Wang TJ*, Tsim KWK*.  Polysaccharide From Tuberous Roots of Ophiopogon japonicus Regulates Gut Microbiota and Its Metabolites During Alleviation of High-fat Diet-induced Type-2 Diabetes in Mice. J Funct Foods. 63:103593.

Wang T, Yan B*, Lou L, Lin X, Yu T, Wu S, Lu Q, Liu W, Huang Z, Zhang M, Zhang W*, Wen Z*.  Nlrc3-like is required for microglia maintenance in zebrafish. J Genet Genomics. 2019 Jun 20;46(6):291-299.

Xu ML, Luk WKW, Liu EYL, Kong XP, Wu QY, Xia YJ, Dong TTX, Tsim KWK*. Differentiation of erythroblast requires the dimeric form of acetylcholinesterase: Interference with erythropoietin receptor. Chem.-Biol. Interact. 308:317-322.

Xu ML, Zheng ZY, Xia YJ, Liu EY, Chan SK, Hu WH, Duan R, Dong TT, Zhan CS, Shang XH, Tsim KW*.  Shexiang Baoxin Pill, a formulated Chinese herbal mixture, induces neuronal differentiation of PC12 cells: a signaling triggered by activation of protein kinase A. Front Pharmacol. 10:1130.

Zhou X, Chen Y, Mok KY, Kwok TCY, Mok VCT, Guo Q, Ip FC, Chen Y, Mullapudi N; Alzheimer’s Disease Neuroimaging Initiative, Giusti-Rodríguez P, Sullivan PF, Hardy J, Fu AKY, Li Y, Ip NY*.  Non-coding variability at the APOE locus contributes to the Alzheimer's risk. Nat Commun. 10(1):3310.