Au FK, Le KTD, Qi RZ. Detection and Analysis of Microtubule Nucleator γ-Tubulin Ring Complex. Methods Mol Biol. 2557:543-558

Chen X, Li Y, Xu J, Cui Y, Wu Q, Yin H, Li Y, Jiang L, Wang H, Wen Z, Yao Z, Wu Z. Styxl2 regulates de novo sarcomere assembly by binding to non-muscle myosin IIs and promoting their degradation eLife 12:RP87434

Dong A, Chan ITC, Cheung TH. ATAC-seq protocol for the profiling of chromatin accessibility of in situ fixed quiescent and activated muscle stem cells. STAR Protoc. 4(3):102376

Fu WY, Ip NY. The role of genetic risk factors of Alzheimer's disease in synaptic dysfunction. Semin Cell Dev Biol. 139:3-12

Gao AX, Xia TC, Lin LS, Dong TT, Tsim KW. The neurotrophic activities of brain-derived neurotrophic factor are potentiated by binding with apigenin, a common flavone in vegetables, in stimulating the receptor signaling. CNS Neurosci Ther. doi: 10.1111/cns.14230

Gao AX, Xia TC, Peng ZT, Wu QY, Zhu Y, Dong TT, Tsim KW. The ethanolic extract of peanut shell attenuates the depressive-like behaviors of mice through modulation of inflammation and gut microbiota. Food Res Int. 168:112765

Guo GX, Wu KY, Zhang XY, Lai FX, Tsim KW, Qin QW, Hu WH. The extract of Curcumae Longae Rhizoma suppresses angiogenesis via VEGF-induced PI3K/Akt-eNOS-NO pathway. J Ethnopharmacol. 308:116299

Guo MS, Wu Q, Dong TT, Tsim KWK. The UV-induced uptake of melanosome by skin keratinocyte is triggered by α7 nicotinic acetylcholine receptor-mediated phagocytosis. FEBS J. 290(3):724-744

Liang Y, Li J, Tian Y, Tang P, Liu C, Chen X. The Anterior Cingulate Cortex Promotes Long-Term Auditory Cortical Responses through an Indirect Pathway via the Rhinal Cortex in Mice. J Neurosci. 43(23):4262-4278

Lin S, Wang X, Guo H, Dai N, Tang RW, Lee HC, Leung KW, Dong TT, Webb SE, Miller AL, Tsim KW. The Ethanol Extract of Evodiae Fructus and Its Ingredient, Rutaecarpine, Inhibit Infection of SARS-CoV-2 and Inflammatory Responses. Int J Mol Sci. 24(1):762

Ospondpant D, Xia Y, Lai QWS, Yuen GK, Yang M, Chanthanam K, Dong TT, Tsim KWK. The extracts of Dracaena cochinchinensis stemwood suppress inflammatory response and phagocytosis in lipopolysaccharide-activated microglial cells. Phytomedicine. 118:154936.

Wu WJ, He SC, Chen YJ, Chen CP, Fu YM, Liu K, Qu JY. Minimally Invasive Microglial and Neuronal Imaging in Mouse Spinal Cord Dorsal Horn. IEEE J Sel Top Quantum Electron. 29(4):7100513

Xia CX, Gao AX, Dong TT, Tsim KW. Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) mimic neurotrophic functions in inducing neurite outgrowth in cultured neurons: Signaling via PI3K/Akt and ERK pathways. Phytomedicine. 115:154832

Xia CX, Gao AX, Zhu Y, Dong TTX, Tsim, KWK. Flavonoids from Seabuckthorn (Hippophae rhamnoides L.) restore CUMS-induced depressive disorder and regulate the gut microbiota in mice. Food Funct. 14(16): 7426-7438

Yang MX, Cheng EHC, Ospondpant, D, Tung KK, Wang LS, Lin SY, Lai, QWS, Wu QY, Xia YJ, Leung KW, Duan R, Dong TTX, Tsim, KWK. The extracts of Lobaria pindarensis, an edible lichen from Himalayas, suppress inflammatory response and fibrillation of amyloid beta-protein in cultured microglial cells: Active depsidones, norstictic acid and stictic acid, are responsible for the functions. J Funct Foods. 107:105607

Yang S, Au FKC, Li G, Lin J, Li XD, Qi RZ. Autoinhibitory mechanism controls binding of centrosomin motif 1 to γ-tubulin ring complex. J Cell Biol. 222(7):e202007101

Yu T, Kuang H, Wu X, Huang Y, Wang J, Wen Z. Cell competition for neuron-derived trophic factor controls the turnover and lifespan of microglia. Sci Adv. 9(24):eadf9790

Zeng W, Zhang W, Tse EHY, Liu J, Dong A, Lam KSW, Luan S, Kung WH, Chan TC, Cheung TH. Restoration of CPEB4 prevents muscle stem cell senescence during aging. Dev Cell. 58(15):1383-1398.e6

Zhao C, Li Y, Tang J, Zhou Q, Lin X, Wen Z. Metaphocytes are IL-22BP-producing cells regulated by ETS transcription factor Spic and essential for zebrafish barrier immunity. Cell Rep. 42(5):112483

Zhou Q, Zhao C, Yang Z, Qu R, Li Y, Fan Y, Tang J, Xie T, Wen Z. Cross-organ single-cell transcriptome profiling reveals macrophage and dendritic cell heterogeneity in zebrafish. Cell Rep. 42(7):112793


Au FKC, Lui ESW, Qi RZ. Protocol to measure inter-centrosome distance in adherent cells using epifluorescence microscopy. STAR Protoc. 3(1):101227.

Cao H, Zhou X, Chen Y, Ip FCF, Chen Y, Lai NCH, Lo RMN, Tong EPS, Mok VCT, Kwok TCY, Alzheimer’s Disease Neuroimaging Initiative, Fu AKY, Ip NY. Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer's Disease Risk. J Alzheimers Dis. 86(4):1861-187

Dong A, Liu J, Lin K, Zeng W, So WK, Hu S, Cheung TH.  Global chromatin accessibility profiling analysis reveals a chronic activation state in aged muscle stem cells. iScience. 25(9):104954

Duan Y, Ye T, Qu Z, Chen Y, Miranda A, Zhou X, Lok KC, Chen Y, Fu AKY, Gradinaru V, Ip NY. Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer's disease alleviates amyloid-related pathologies in mice. Nat Biomed Eng.6(2):168-180

Fan R, Lai KO. Understanding how kinesin motor proteins regulate postsynaptic function in neuron. FEBS J. 289(8):2128-2144

Gao AX, Xia TC, Mak MS, Zhu KY, Dong TT, Tsim KW. A Herbal Mixture of Sesami Semen Nigrum and Longan Arillus Induces Neurite Outgrowth in Cultured Neurons and Shows Anti-Depression in Chronic Mild Stress-Induced Rats. Evid Based Complement Alternat Med. 2022:8809546

Gao AX, Xiao J, Xia TC, Dong TX, Tsim,KWK. The extract of peanut shell enhances neurite outgrowth of neuronal cells: Recycling of agricultural waste for development of nutraceutical products. J Funct Foods. 91: 105023

Guo MS, Gao X, Hu W, Wang X, Dong TT, Tsim KWK. Scutellarin potentiates the skin regenerative function of self growth colony, an optimized platelet-rich plasma extract, in cultured keratinocytes through VEGF receptor and MAPK signaling. J Cosmet Dermatol. doi: 10.1111/jocd.14800

Han L, Wang G, Zhou S, Situ C, He Z, Li Y, Qiu Y, Huang Y, Xu A, Ong MTY, Wang H, Zhang J, Wu Z. Muscle satellite cells are impaired in type 2 diabetic mice by elevated extracellular adenosine. Cell Rep. 39(9):110884

Hu WH, Zhang XY, Leung KW, Duan R, Dong TT, Qin QW, Tsim KW. Resveratrol, an Inhibitor Binding to VEGF, Restores the Pathology of Abnormal Angiogenesis in Retinopathy of Prematurity (ROP) in Mice: Application by Intravitreal and Topical Instillation. Int J Mol Sci. 23(12):6455

Jiang Y, Zhou X, Wong HY, Ouyang L, Ip FCF, Chau VMN, Lau SF, Wu W, Wong DYK, Seo H, Fu WY, Lai NCH, Chen Y, Chen Y, Tong EPS; Alzheimer’s Disease Neuroimaging Initiative; Mok VCT, Kwok TCY, Mok KY, Shoai M, Lehallier B, Losada PM, O'Brien E, Porter T, Laws SM, Hardy J, Wyss-Coray T, Masters CL, Fu AKY, Ip NY. An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer's disease. Nat Aging. 2(7):616-634

Lai QWS, Fan Q, Zheng BZ, Chen Y, Dong TT, Tsim KWK. Edible bird's nest, an Asian health food supplement, possesses anti-inflammatory responses in restoring the symptoms of atopic dermatitis: An analysis of signaling cascades. Front Pharmacol. 13:941413

Lam YS, Liu XX, Ke Y, Yung WH. Edge-based network analysis reveals frequency-specific network dynamics in aberrant anxiogenic processing in rats. Netw Neurosci. 6(3):816-833

Li X, Chen SC, Ip JPK. Diverse and Composite Roles of miRNA in Non-Neuronal Cells and Neuronal Synapses in Alzheimer's Disease. Biomolecules. 12(10):1505

Lin S, Wang X, Tang RW, Lee HC, Chan HH, Choi SSA, Dong TT, Leung KW, Webb SE, Miller AL, Tsim KW. The Extracts of Polygonum cuspidatum Root and Rhizome Block the Entry of SARS-CoV-2 Wild-Type and Omicron Pseudotyped Viruses via Inhibition of the S-Protein and 3CL Protease. Molecules. 27(12):3806

Lou L, Yu T, Dai Y, Zhao S, Feng S, Xu J, Wen Z. Mafba and Mafbb regulate microglial colonization of zebrafish brain via controlling chemotaxis receptor expression. Proc Natl Acad Sci U S A. 119(39):e2203273119

Ospondpant D, Gao X, Dong TT, Tsim KWK. Dracaena cochinchinensis stemwood extracts inhibit amyloid-β fibril formation and promote neuronal cell differentiation. Front Pharmacol. 13:943638.

Qin Z, She Z, Chen C, Wu W, Lau JKY, Ip NY, Qu JY. Deep tissue multi-photon imaging using adaptive optics with direct focus sensing and shaping. Nat Biotechnol. 40(11):1663-1671

Sun W, Tang P, Liang Y, Li J, Feng J, Zhang N, Lu D, He J, Chen X. The anterior cingulate cortex directly enhances auditory cortical responses in air-puffing-facilitated flight behavior. Cell Rep. 38(10):110506

Wang X, Lin S, Tang RW, Lee HC, Chan HH, Choi SSA, Leung KW, Webb SE, Miller AL, Tsim KW. Polygoni multiflori radix extracts inhibit SARS-CoV-2 pseudovirus entry in HEK293T cells and zebrafish larvae. Phytomedicine. 102:154154

Wong HY, Zhong H, Zhong M, Zhou X, Chan PYC, Kwok TCY, Mok K, Hardy J, Ip FCF, Fu AKY, Ip NY. Demographics and Medication Use of Patients with Late-Onset Alzheimer’s Disease in Hong Kong. J Alzheimer's Dis. 87:1205–1213

Wu J, Peng Z, Wu Q, Tang RWL, Dong T, Wang H, Tsim KWK. The water extract of Aloe vera prevents fluoxetine-induced multiple-drug resistance of E. coli by inhibiting reactive oxygen species formation and membrane permeability. Phytomedicine.106:154421

Wu Q, Bai P, Guo H, Guo MSS, Xia Y, Xia Y, Gao X, Wang X, Wu J, Dong TTX, Tsim KWK. Capsaicin, a Phytochemical From Chili Pepper, Alleviates the Ultraviolet Irradiation-Induced Decline of Collagen in Dermal Fibroblast via Blocking the Generation of Reactive Oxygen Species. Front Pharmacol. 13:872912

Wu W, He S, Wu J, Chen C, Li X, Liu K, Qu JY. Long-term in vivo imaging of mouse spinal cord through an optically cleared intervertebral window. Nat Commun. 13(1):1959

Xia YT, Wu QY, Cheng EHC, Dong TTX, Qin QW, Wang WX, Tsim KWK. The inclusion of extract from aerial part of Scutellaria baicalensis in feeding of pearl gentian grouper (Epinephelus fuscoguttatus♀ × Epinephelus lanceo-latus♂) promotes growth and immunity. Fish Shellfish Immunol. 127:521-529

Xia Y, Wu Q, Mak S, Liu EYL, Zheng BZY, Dong TTX, Pi R, Tsim KWK. Regulation of acetylcholinesterase during the lipopolysaccharide-induced inflammatory responses in microglial cells. FASEB J. 36(3):e22189

Yu QC, Geng A, Preusch CB, Chen Y, Peng G, Xu Y, Jia Y, Miao Y, Xue H, Gao D, Bao L, Pan W, Chen J, Garcia KC, Cheung TH, Zeng YA. Activation of Wnt/β-catenin signaling by Zeb1 in endothelial progenitors induces vascular quiescence entry. Cell Rep. 41(8):111694

Yuen GK, Ho BS, Lin LS, Dong TT, Tsim KW. Tectoridin Stimulates the Activity of Human Dermal Papilla Cells and Promotes Hair Shaft Elongation in Mouse Vibrissae Hair Follicle Culture. Molecules. 27(2):400

Zeng W, Yue L, Lam KSW, Zhang W, So WK, Tse EHY, Cheung TH. CPEB1 directs muscle stem cell activation by reprogramming the translational landscape. Nat Commun. 13(1):947

Zhao S, Feng S, Tian Y, Wen Z. Hemogenic and aortic endothelium arise from a common hemogenic angioblast precursor and are specified by the Etv2 dosage. Proc Natl Acad Sci U S A. 119(13):e2119051119

Zhao S, Zhang A, Zhu H, Wen Z. The ETS transcription factor Spi2 regulates hematopoietic cell development in zebrafish. Development. 149(19):dev200881

Zhou S, Han L, Wu Z. A Long Journey before Cycling: Regulation of Quiescence Exit in Adult Muscle Satellite Cells. Int J Mol Sci. 23(3):1748


Chan GKL, Guo MS, Dai DK, Lai QWS, Fung KWC, Zheng BZ, Wu KQ, Man BKK, Dong TT, Tsim KWK. An Optimized Extract, Named Self-Growth Colony, from Platelet-Rich Plasma Shows Robust Skin Rejuvenation and Anti-Ageing Properties: A Novel Technology in Development of Cosmetics. Skin Pharmacol Physiol. 34(2):74-85

Chen C, Qin Z, He S, Liu S, Lau SF, Wu W, Zhu D, Ip NY, Qu JY. High-resolution two-photon transcranial imaging of brain using direct wavefront sensing. Photonics Res. 9(6):1144-1156

Chen C, She Z, Tang P, Qin Z, He J, Qu JY. Study of neurovascular coupling by using mesoscopic and microscopic imaging. iScience. 24(10):103176

Chung YK, Wong YH. Re-examining the 'Dissociation Model' of G protein activation from the perspective of Gβγ signaling. FEBS J. 288(8):2490-2501

Dong A, Cheung TH. Deciphering the chromatin organization and dynamics for muscle stem cell function. Curr Opin Cell Biol. 73:124-132

Dong R, Li X, Lai KO. Activity and Function of the PRMT8 Protein Arginine Methyltransferase in Neurons. Life (Basel). 11(11):1132

Feng H, Su J, Fang W, Chen X, He J. The entorhinal cortex modulates trace fear memory formation and neuroplasticity in the mouse lateral amygdala via cholecystokinin. Elife. 10:e69333

Fu WY, Hung KW, Lau SF, Butt B, Yuen VW, Fu G, Chan IC, Ip FCF, Fu AKY, Ip NY. Rhynchophylline Administration Ameliorates Amyloid-β Pathology and Inflammation in an Alzheimer's Disease Transgenic Mouse Model. ACS Chem Neurosci. 12(22):4249-4256

Gong G, Yu H, Zheng Y, Qi B, He H, Yin T, Dong TT, Tsim KW. Astragaloside IV, a saponin from Astragalus membranaceus var. mongholicus, induces expressions of heme recycle proteins via signaling of Nrf2/ARE in cultured macrophages. J Ethnopharmacol. 265:113389

Guo MS, Wu Q, Lai QWS, Wang X, Bai P, Fung KWC, Dong TT, Tsim KWK. A prepared platelet-rich plasma extract, namely Self-Growth Colony, inhibits melanogenesis by down-regulating microphthalmia-associated transcription factor in skin melanocyte. J Cosmet Dermatol. 20(10):3278-3288

He X, Urip BA, Zhang Z, Ngan CC, Feng B. Evolving AAV-delivered therapeutics towards ultimate cures. J Mol Med (Berl). 99(5):593-617

Hu WH, Dai DK, Zheng BZ, Duan R, Chan GK, Dong TT, Qin QW, Tsim KW. The binding of kaempferol-3-O-rutinoside to vascular endothelial growth factor potentiates anti-inflammatory efficiencies in lipopolysaccharide-treated mouse macrophage RAW264.7 cells. Phytomedicine. 80:153400

Ip FCF, Fu G, Yang F, Kang F, Sun P, Ling CY, Cheung K, Xie F, Hu Y, Fu L, Ip NY. A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice. Eur J Med Chem. 226:113827

Jiang Y, Zhou X, Ip FC, Chan P, Chen Y, Lai NCH, Cheung K, Lo RMN, Tong EPS, Wong BWY, Chan ALT, Mok VCT, Kwok TCY, Mok KY, Hardy J, Zetterberg H, Fu AKY, Ip NY. Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and staging. Alzheimers Dement. 18(1):88-102

Konovalov KA, Wang W, Wang G, Goonetilleke EC, Gao X, Wang D, Huang X. A comprehensive mechanism for 5-carboxylcytosine-induced transcriptional pausing revealed by Markov state models. J Biol Chem. 296:100735

Kwan KKL, Yun H, Dong TTX, Tsim KWK. Ginsenosides attenuate bioenergetics and morphology of mitochondria in cultured PC12 cells under the insult of amyloid beta-peptide. J Ginseng Res. 45(4):473-481

Kwan KKL, Wong, TY, Yu AXD, Dong TTX, Lam HHL, Tsim KWK. The Osteogenic Function of Danggui Buxue Tang, a Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, Is Optimized by Boiling the Two Herbs Together: Signaling Analyses Revealed by Systems Biology. Processes.  9(7):1119

Kwan KKL, Dong TTX, Tsim KWK. Danggui Buxue Tang, a Chinese herbal decoction containing Astragali Radix and Angelicae Sinensis Radix, improves mitochrondial bioenergetics in osteoblast. Phytomedicine. 88:153605

Kwan KKL, Wong TY, Yu AXD, Dong TTX, Lam HHN, Tsim KWK. Integrated Omics Reveals the Orchestrating Role of Calycosin in Danggui Buxue Tang, a Herbal Formula Containing Angelicae Sinensis Radix and Astragali Radix, in Inducing Osteoblastic Differentiation and Proliferation. Front Pharmacol. 12:670947

Lai QWS, Guo MSS, Wu KQ, Liao Z, Guan D, Dong TT, Tong P, Tsim KWK. Edible Bird's Nest, an Asian Health Food Supplement, Possesses Moisturizing Effect by Regulating Expression of Filaggrin in Skin Keratinocyte. Front Pharmacol. 12:685982

Lau J, Tian M, Shen Y, Lau SF, Fu WY, Fu AK, Ip NY. Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model. Sci Rep. 11(1):4359

Lau SF, Fu AKY, Ip NY. Cytokine signaling convergence regulates the microglial state transition in Alzheimer's disease. Cell Mol Life Sci. 78(10):4703-4712

Lau SF, Wu W, Seo H, Fu AKY, Ip NY. Quantitative in vivo assessment of amyloid-beta phagocytic capacity in an Alzheimer's disease mouse model. STAR Protoco. 2(1):100265

Li C, Liu Z, Goonetilleke EC, Huang X. Temperature-dependent kinetic pathways of heterogeneous ice nucleation competing between classical and non-classical nucleation. Nat Commun. 12(1):4954

Liao C, Xu J, Chen Y, Ip NY. Retinal Dysfunction in Alzheimer's Disease and Implications for Biomarkers. Biomolecules. 11(8):1215

Liu EYL, Mak S, Kong X, Xia Y, Kwan KKL, Xu ML, Tsim KWK. Tacrine Induces Endoplasmic Reticulum-Stressed Apoptosis via Disrupting the Proper Assembly of Oligomeric Acetylcholinesterase in Cultured Neuronal Cells. Mol Pharmacol. 100(5):456-469

Tse LH, Wong YH. Modeling the Heterodimer Interfaces of Melatonin Receptors. Front Cell Neurosci. 15:725296

Unarta IC, Cao S, Kubo S, Wang W, Cheung PP, Gao X, Takada S, Huang X. Role of bacterial RNA polymerase gate opening dynamics in DNA loading and antibiotics inhibition elucidated by quasi-Markov State Model. Proc Natl Acad Sci U S A. 118(17):e2024324118

Unarta IC, Xu J, Shang Y, Cheung CHP, Zhu R, Chen X, Cao S, Cheung PP, Bierer D, Zhang M, Huang X, Li X. Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain. RSC Chem Biol. 2(4):1274-1284

Urbán N, Cheung TH. Stem cell quiescence: the challenging path to activation. Development. 148(3):dev165084

Wang X, Unarta IC, Cheung PP, Huang X. Elucidating molecular mechanisms of functional conformational changes of proteins via Markov state models. Curr Opin Struct Biol. 67:69-77

Wang X, Ye F, Wen Z, Guo Z, Yu C, Huang WK, Rojas Ringeling F, Su Y, Zheng W, Zhou G, Christian KM, Song H, Zhang M, Ming GL. Structural interaction between DISC1 and ATF4 underlying transcriptional and synaptic dysregulation in an iPSC model of mental disorders. Mol Psychiatry. 26(4):1346-1360.

Wang Y, Chong TH, Unarta IC, Xu X, Suarez GD, Wang J, Lis JT, Huang X, Cheung PP. EmPC-seq: Accurate RNA-sequencing and Bioinformatics Platform to Map RNA Polymerases and Remove Background Error. Bio Protoc.11(4):e3921

Wang Y, Fu AKY, Ip NY. IL-33/ST2 Signaling Regulates Synaptic Plasticity and Homeostasis in the Adult Hippocampal Circuitry. DNA Cell Biol. 40(9):1125-1130

Wang Y, Fu AKY, Ip NY. Instructive roles of astrocytes in hippocampal synaptic plasticity: neuronal activity-dependent regulatory mechanisms. FEBS J. 289(8):2202-2218

Wang Y, Fu WY, Cheung K, Hung KW, Chen C, Geng H, Yung WH, Qu J, Fu AK, Ip NY. Astrocyte-secreted IL-33 mediates homeostatic synaptic plasticity in the adult hippocampus. Proc Natl Acad Sci U S A. 118(1):e2020810118

Wong KM, Song J, Wong YH. CTCF and EGR1 suppress breast cancer cell migration through transcriptional control of Nm23-H1. Sci Rep. 11(1):491

Wu W, Li X, Qu JY, He S. In vivo Imaging of Biological Tissues with Combined Two-Photon Fluorescence and Stimulated Raman Scattering Microscopy. J Vis Exp. (178). doi: 10.3791/63411

Xia Y, Cheng HC, Xia Y, Wu Q, Zhang HL, Lin S, Dong TT, Qin QW, Wang W, Tsim KW. Characterization of a macrophagic-like cell line derived from rabbit fish (Siganus fuscescens): An illustration of anti-inflammatory responses of the herbal extract of Scutellaria baicalensis. Fish Shellfish Immunol Rep. 2:100036

Xia YT, Cheng EH, Zheng BZ, Wu QY, Dong TT, Duan R, Qin QW, Wang WX, Tsim KW. Feeding containing the aerial part of Scutellaria baicalensis promotes the growth and nutritive value of rabbit fish Siganus fuscescens. Food Sci Nutr. 9(9):4827-4838

Xiong Gao A, Xia TC, Shing-Hung Mak M, Kin-Leung Kwan K, Zhong-Yu Zheng B, Xiao J, Dong TT, Tsim KW. Luteolin stimulates the NGF-induced neurite outgrowth in cultured PC12 cells through binding with NGF and potentiating its receptor signaling. Food Funct. 12(22):11515-11525

Xu P, Chang JC, Zhou X, Wang W, Bamkole M, Wong E, Bettayeb K, Jiang LL, Huang T, Luo W, Xu H, Nairn AC, Flajolet M, Ip NY, Li YM, Greengard P. GSAP regulates lipid homeostasis and mitochondrial function associated with Alzheimer's disease. J Exp Med. 218(8):e20202446

Xu X, Zhang L, Chu JTS, Wang Y, Chin AWH, Chong TH, Dai Z, Poon LLM, Cheung PP, Huang X. A novel mechanism of enhanced transcription activity and fidelity for influenza A viral RNA-dependent RNA polymerase. Nucleic Acids Res. 49(15):8796-8810

Ye T, Duan Y, Tsang HWS, Xu H, Chen Y, Cao H, Chen Y, Fu AKY, Ip NY. Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases. Commun Biol. 4(1):195

Yin C, Lui ESW, Jiang T, Qi RZ. Proteolysis of γ-tubulin small complex proteins is mediated by the ubiquitin-proteasome system. FEBS Lett. doi: 10.1002/1873-3468.14146

Yu AX, Xiao J, Zhao SZ, Kong XP, Kwan KK, Zheng BZ, Wu KQ, Dong TT, Tsim KW. Biological Evaluation and Transcriptomic Analysis of Corylin as an Inhibitor of Osteoclast Differentiation. Int J Mol Sci. 22(7):3540

Zhang L, Zhang D, Wang X, Yuan C, Li Y, Jia X, Gao X, Yen HL, Cheung PP, Huang X. 1'-Ribose cyano substitution allows Remdesivir to effectively inhibit nucleotide addition and proofreading during SARS-CoV-2 viral RNA replication. Phys Chem Chem Phys. 23(10):5852-5863

Zhou S, Han L, Weng M, Zhu H, Heng Y, Wang G, Shen Z, Chen X, Fu X, Zhang M, Wu Z. Paxbp1 controls a key checkpoint for cell growth and survival during early activation of quiescent muscle satellite cells. Proc Natl Acad Sci U S A. 118(13):e2021093118

Zhou X, Chen C, Ip FC, Jiang Y, Cao H, Zhong H, Chen J, Ye T, Chen Y, Zhang Y, Ma S, Lo RM, Tong EP, Alzheimer’s Disease Neuroimaging Initiative, Mok VC, Kwok TC, Guo Q, Mok KY, Shoai M, Hardy J, Chen L, Fu AK, Ip NY. Deep learning methods improve polygenic risk analysis and prediction for Alzheimer’s disease. Res Sq. 1–30. doi:10.21203/

Zhou X, Fu AK, Ip NY. APOE signaling in neurodegenerative diseases: an integrative approach targeting APOE coding and noncoding variants for disease intervention. Curr Opin Neurobiol. 69:58-67


Au FKC, Hau BKT, Qi RZ. Nek2-mediated GAS2L1 phosphorylation and centrosome-linker disassembly induce centrosome disjunction. J Cell Biol. 219(5):e201909094

Chan KH, Tse LH, Huang X, Wong YH. Molecular basis defining the selectivity of substituted isoquinolinones for the melatonin MT2 receptor. Biochem Pharmacol. 177:114020

Chen J, Tsim KWK. A Review of Edible Jujube, the Ziziphus jujuba Fruit: A Heath Food Supplement for Anemia Prevalence. Front Pharmacol. 11:593655

Cheung PP, Jiang B, Booth GT, Chong TH, Unarta IC, Wang Y, Suarez GD, Wang J, Lis JT, Huang X. Identifying Transcription Error-Enriched Genomic Loci Using Nuclear Run-on Circular-Sequencing Coupled with Background Error Modeling. J Mol Biol. 432(13):3933-3949

Dong A, Preusch CB, So WK, Lin K, Luan S, Yi R, Wong JW, Wu Z, Cheung TH. A long noncoding RNA, LncMyoD, modulates chromatin accessibility to regulate muscle stem cell myogenic lineage progression. Proc Natl Acad Sci U S A.117(51):32464-32475

Gong G, Xie F, Zheng Y, Hu W, Qi B, He H, Dong TT, Tsim KW. The effect of methanol extract from Saussurea involucrata in the lipopolysaccharide-stimulated inflammation in cultured RAW 264.7 cells. J Ethnopharmacol. 251:112532

Guo R, Guo S, Gao X, Wang H, Hu W, Duan R, Dong TTX, Tsim KWK. Fermentation of Danggui Buxue Tang, an ancient Chinese herbal mixture, together with Lactobacillus plantarum enhances the anti-diabetic functions of herbal product. Chin Med. 15:98

He S, Tian Y, Feng S, Wu Y, Shen X, Chen K, He Y, Sun Q, Li X, Xu J, Wen Z, Qu JY. In vivo single-cell lineage tracing in zebrafish using high-resolution infrared laser-mediated gene induction microscopy. eLife. 9:e52024

He S, Wei X, Qin Z, Chen C, Wu Z, Qu JY. In vivo study of metabolic dynamics and heterogeneity in brown and beige fat by label-free multiphoton redox and fluorescence lifetime microscopy. J Biophotonics. 13(2):e201960057

He S, Xu J, Qu JY, Wen Z. Lightening the way of hematopoiesis: Infrared laser-mediated lineage tracing with high spatial-temporal resolution. Exp Hematol. 85:3-7

Hu WH, Dai DK, Zheng BZ, Duan R, Dong TT, Qin QW, Tsim KW. Piceatannol, a Natural Analog of Resveratrol, Exerts Anti-angiogenic Efficiencies by Blockage of Vascular Endothelial Growth Factor Binding to Its Receptor. Molecules. 25(17):3769

Hu WH, Mak SH, Zheng ZY, Xia YJ, Xu ML, Duan R, Dong TT, Li SP, Zhan CS, Shang XH, Tsim KW. Shexiang Baoxin Pill, a Traditional Chinese Herbal Formula, Rescues the Cognitive Impairments in APP/PS1 Transgenic Mice. Front Pharmacol.11:1045

Hu WH, Wang HY, Xia YT, Dai DK, Xiong QP, Dong TT, Duan R, Chan GK, Qin QW, Tsim KW. Kaempferol, a Major Flavonoid in Ginkgo Folium, Potentiates Angiogenic Functions in Cultured Endothelial Cells by Binding to Vascular Endothelial Growth Factor. Front Pharmacol. 11:526

Huang Y, Yao P, Leung KW, Wang H, Kong XP, Dong TTX, Chen Y, Qin QW, Tsim KWK. The Chinese medicinal herbs of spleen-meridian property regulate body temperature in yeast-induced fever rats. Phytomedicine. 74:152815

Kong X, Chen Z, Xia Y, Liu EYL, Ren H, Wang C, Hu WWH, Dong TTX, Pi R, Tsim KWK. Dehydrocorydaline Accounts the Majority of Anti-Inflammatory Property of Corydalis Rhizoma in Cultured Macrophage. Evid Based Complement Alternat Med. 2020:4181696

Kong XP, Ren HQ, Liu EYL, Leung KW, Guo SC, Duan R, Dong TTX, Tsim KWK. The Cholinesterase Inhibitory Properties of Stephaniae Tetrandrae Radix. Molecules. 25(24):5914

Lau SF, Cao H, Fu AK, Ip NY.  Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer's disease. Proc Natl Acad Sci U S A.117(41):25800-25809

Lau SF, Chen C, Fu WY, Qu JY, Cheung TH, Fu AKY, Ip NY. IL-33-PU.1 Transcriptome Reprogramming Drives Functional State Transition and Clearance Activity of Microglia in Alzheimer's Disease. Cell Rep. 31(3):107530

Li Y, Liu W, Saini V, Wong YH. Mutations at the dimer interface and surface residues of Nm23-H1 metastasis suppressor affect its expression and function. Mol Cell Biochem. 474(1-2):95-112

Lin L, Lyu Q, Kwan PY, Zhao J, Fan R, Chai A, Lai CSW, Chan YS, Shen X, Lai KO. The epilepsy and intellectual disability-associated protein TBC1D24 regulates the maintenance of excitatory synapses and animal behaviors. PLoS Genet. 16(1):e1008587

Liu EY, Zheng ZX, Zheng BZ, Xia Y, Guo MS, Dong TT, Tsim KWK. Tectorigenin, an isoflavone aglycone from the rhizome of Belamcanda chinensis, induces neuronal expression of erythropoietin via accumulation of hypoxia-inducible factor-1α. Phytother Res. 34(6):1329-1337

Liu EYL, Xia Y, Kong X, Guo MSS, Yu AXD, Zheng BZY, Mak S, Xu ML, Tsim KWK. Interacting with α 7 nAChR is a new mechanism for AChE to enhance the inflammatory response in macrophages. Acta Pharm Sin B. 10(10):1926-1942

Liu Z, Yang Y, Gu A, Xu J, Mao Y, Lu H, Hu W, Lei QY, Li Z, Zhang M, Cai Y, Wen W. Par complex cluster formation mediated by phase separation. Nat Commun. 11(1):2266

Lo LH, Dong R, Lyu Q, Lai KO. The protein arginine methyltransferase PRMT8 and substrate G3BP1 control Rac1-PAK1 signaling and actin cytoskeleton for dendritic spine maturation. Cell Rep. 31(10):107744

Lo LH, Lai KO. Dysregulation of protein synthesis and dendritic spine morphogenesis in ASD: studies in human pluripotent stem cells. Mol Autism. 11(1):40

Luo W, Ip FC, Fu G, Cheung K, Tian Y, Hu Y, Sinha A, Cheng E, Wu X, Bustos V, Greengard P, Li Y, Sinha SC, Ip NY. A pentacyclic triterpene from Ligustrum lucidum targets γ-secretase. ACS Chem Neurosci. 11(18):2827-2835

Mu MD, Qian ZM, Yang SX, Rong KL, Yung WH, Ke Y. Therapeutic effect of a histone demethylase inhibitor in Parkinson's disease. Cell Death Dis. 11(10):927

Ouyang L, Chen Y, Wang Y, Chen Y, Fu AK, Fu WY, Ip NY. p39-associated Cdk5 activity regulates dendritic morphogenesis. Sci Rep. 10(1):18746

Pan C, Liu C, Peng J, Ren P, Huang X. Three‐site and five‐site fixed‐charge water models compatible with AMOEBA force field. J Comput Chem. 41:1034–1044

Peng S, Wang X, Zhang L, He S, Zhao XS, Huang X, Chen C. Target search and recognition mechanisms of glycosylase AlkD revealed by scanning FRET-FCS and Markov state models. Proc Natl Acad Sci U S A. 117(36):21889-21895

Qin Z, Chen C, He S, Wang Y, Tam KF, Ip NY, Qu JY. Adaptive optics two-photon endomicroscopy enables deep-brain imaging at synaptic resolution over large volumes. Sci Adv. 6(40):eabc6521

Qin Z, He S, Yang C, Yung JS, Chen C, Leung CK, Liu K, Qu JY. Adaptive optics two-photon microscopy enables near-diffraction-limited and functional retinal imaging in vivo. Light Sci Appl. 9:79

Wang J, Zhang C, Feng B. The rapidly advancing Class 2 CRISPR-Cas technologies: A customizable toolbox for molecular manipulations. J Cell Mol Med. 24(6):3256–3270

Wu Q, Bai P, Xia Y, Lai QWS, Guo MSS, Dai K, Zheng Z, Ling CSJ, Dong TTX, Pi R, Tsim KWK. Solar light induces expression of acetylcholinesterase in skin keratinocytes: Signalling mediated by activator protein 1 transcription factor. Neurochem Int. 141:104861

Wu Q, Bai P, Xia Y, Xia Y, Xu B, Dai K, Zheng Z, Guo MSS, Fung KWC, Dong TTX, Tsim KWK. Capsaicin Inhibits the Expression of Melanogenic Proteins in Melanocyte via Activation of TRPV1 Channel: Identifying an Inhibitor of Skin Melanogenesis. J Agric Food Chem. 68(50):14863-14873

Wu Q, Xia Y, Dai K, Bai P, Kwan KKL, Guo MSS, Dong TTX, Tsim KWK. Solar light induces the release of acetylcholine from skin keratinocytes affecting melanogenesis. FASEB J. 34(7):8941-8958

Wu S, Nguyen LTM, Pan H, Hassan S, Dai Y, Xu J, Wen Z. Two phenotypically and functionally distinct microglial populations in adult zebrafish. Sci Adv. 6(47):eabd1160

Xia YT, Chan GKL, Wang HY, Dong TTX, Duan R, Hu WH, Qin QW, Wang WX, Tsim KWK. The anti-bacterial effects of aerial parts of Scutellaria baicalensis: Potential application as an additive in aquaculture feedings. Aquaculture. 526:735418

Xia YT, Hu WH, Wu QY, Dong TT, Duan R, Xiao J, Li SP, Qin QW, Wang WX, Tsim KW. The herbal extract deriving from aerial parts of Scutellaria baicalensis shows anti-inflammation and anti-hypoxia responses in cultured fin cells from rabbit fish. Fish Shellfish Immunol. 106:71-78

Yip JLK, Lee MMK, Leung CCY, Tse MK, Cheung AST, Wong YH. AGS3 and Gαi3 Are Concomitantly Upregulated as Part of the Spindle Orientation Complex during Differentiation of Human Neural Progenitor Cells. Molecules. 25(21):5169

Yu AX, Xu ML, Yao P, Kwan KK, Liu YX, Duan R, Dong TT, Ko RK, Tsim KW. Corylin, a flavonoid derived from Psoralea Fructus, induces osteoblastic differentiation via estrogen and Wnt/β-catenin signaling pathways. FASEB J. 34(3):4311-4328

Yu T, Kuang H, Chen J, Lin X, Wu Y, Chen K, Zhang M, Zhang W, Wen Z. Tripartite-motif family protein 35-28 regulates microglia development by preventing necrotic death of microglial precursors in zebrafish. J Biol Chem. 295(26):8846-8856

Yue L, Cheung TH. Protocol for Isolation and Characterization of In Situ Fixed Quiescent Muscle Stem Cells. STAR Protoc. 1(3):100128

Yue L, Wan R, Luan S, Zeng W, Cheung TH. Dek Modulates Global Intron Retention during Muscle Stem Cells Quiescence Exit. Dev Cell. 53(6):661-676.e6

Zhang Z, Zheng X, Sun W, Peng Y, Guo Y, Lu D, Zheng Y, Li X, Jendrichovsky P, Tang P, He L, Li M, Liu Q, Xu F, Ng G, Chen X, He J. Visuoauditory Associative Memory Established with Cholecystokinin Under Anesthesia Is Retrieved in Behavioral Contexts. J Neurosci. 40(10):2025-2037

Zhao J, Fok AHK, Fan R, Kwan PY, Chan HL, Lo LHY, Chan YS, Yung WH, Huang J, Lai CSW, Lai KO. Specific depletion of the motor protein KIF5B leads to deficits in dendritic transport, synaptic plasticity and memory. eLife. 9:e53456

Zheng Y, Xin G, Gong G, Dong TT, Li P, Tsim KWK. Evaluation of Anti-Inflammatory Components of Guizhi Fuling Capsule, an Ancient Chinese Herbal Formula, in Human Umbilical Vein Endothelial Cells. Evid Based Complement Alternat Med. 2020:2029134

Zhou X, Chen Y, Ip FC, Lai NC, Li YY, Jiang Y, Zhong H, Chen Y, Zhang Y, Ma S, Lo RM, Cheung K, Tong EP, Ko H, Shoai M, Mok KY, Hardy J, Mok VC, Kwok TC, Fu AK, Ip NY. Genetic and polygenic risk score analysis for Alzheimer’s disease in the Chinese population. Alzheimers Dement (Amst). 12(1):e12074


Chen WW, Fu WY, Su YT, Fang WQ, Fu AKY, Ip NY. Increased Axin expression enhances adult hippocampal neurogenesis and exerts an antidepressant effect. Sci Rep. 9(1):1190

Chen Y, Fu AKY, Ip NY. Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies. Pharmacol Ther. 195:186-198

Chen Y, Xu J, Zhou X, Liu S, Zhang Y, Ma S, Fu AKY, Ip NY, Chen Y. Changes of protein phosphorylation are associated with synaptic functions during the early stage of Alzheimer's Disease. ACS Chem Neurosci. 10(9):3986-3996

Fu WY, Wang X, Ip NY. Targeting Neuroinflammation as a Therapeutic Strategy for Alzheimer's Disease: Mechanisms, Drug Candidates, and New Opportunities. ACS Chem Neurosci. 10(2):872-879

Hu WH, Chan GK, Duan R, Wang HY, Kong XP, Dong TT, Tsim KW. Synergy of Ginkgetin and Resveratrol in Suppressing VEGF-Induced Angiogenesis: A Therapy in Treating Colorectal Cancer. Cancers (Basel). 11(12):1828

Hu WH, Duan R, Xia YT, Xiong QP, Wang HY, Chan GK, Liu SY, Dong TT, Qin QW, Tsim KW. Binding of Resveratrol to Vascular Endothelial Growth Factor Suppresses Angiogenesis by Inhibiting the Receptor Signaling. J Agric Food Chem.67(4):1127-1137

Hu WH, Wang HY, Kong XP, Xiong QP, Poon KK, Xu L, Duan R, Chan GK, Dong TT, Tsim KW. Polydatin suppresses VEGF-induced angiogenesis through binding with VEGF and inhibiting its receptor signaling. FASEB J. 33(1):532-544

Huang Y, Kwan KKL, Leung KW, Yao P, Wang H, Dong TT, Tsim KWK. Ginseng extracts modulate mitochondrial bioenergetics of live cardiomyoblasts: a functional comparison of different extraction solvents. J Ginseng Res. 43(4):517-526

Jin Y, Wang CY, Hu WH, Huang Y, Xu ML, Wang HY, Kong XP, Chen YC, Dong TT, Qin QW, Tsim KWK. An optimization of ultra-sonication-assisted extraction from flowers of Apocynum venetum in targeting to amount of free amino acids determined by UPLC-MS/MS. Food Qual Saf. 3(1):52-60

Kong XP, Liu EYL, Chen ZC, Xu ML, Yu AXD, Wu QY, Xia YJ, Duan R, Dong TTX, Tsim KWK. Synergistic inhibition of acetylcholinesterase by alkaloids derived from Stephaniae Tetrandrae Radix, Coptidis Rhizoma and Phellodendri Chinensis Cortex. Molecules. 24(24):4567

Kwan KKL, Huang Y, Leung KW, Dong TTX, Tsim KWK. Danggui Buxue Tang, a Chinese Herbal Decoction Containing Astragali Radix and Angelicae Sinensis Radix, Modulates Mitochondrial Bioenergetics in Cultured Cardiomyoblasts. Front Pharmacol. 10:614

Lam KYC, Wu QY, Hu WH, Yao P, Wang HY, Dong TTX, Tsim KWK. Asarones from Acori Tatarinowii Rhizoma stimulate expression and secretion of neurotrophic factors in cultured astrocytes. Neurosci Lett. 707:134308

Lei J, Sheng G, Cheung PP, Wang S, Li Y, Gao X, Zhang Y, Wang Y, Huang X. Two symmetric arginine residues play distinct roles in Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc Natl Acad Sci U S A. 116(3):845-853

Liu EYL, Xu ML, Xia Y, Kong X, Wu Q, Dong TTX, Tsim KWK. Activation of G protein-coupled receptor 30 by flavonoids leads to expression of acetylcholinesterase in cultured PC12 cells. Chem Biol Interact. 306:147-151

Shen Y, Wang K, Qi RZ. The catalytic subunit of DNA polymerase δ is a nucleocytoplasmic shuttling protein. Exp Cell Res. 375(2):36-40

Su YT, Lau SF, Ip JPK, Cheung K, Cheung THT, Fu AKY, Ip NY. α2-Chimaerin is essential for neural stem cell homeostasis in mouse adult neurogenesis. Proc Natl Acad Sci U S A. 116(27):13651-13660

Tse CKM, Xu J, Xu L, Sheong FK, Wang S, Chow HY, Gao X, Li X, Cheung PP, Wang D, Zhang Y, Huang X. Intrinsic Cleavage of RNA Polymerase II Adopts a Nucleobase-independent Mechanism Assisted by Transcript Phosphate. Nat Energy. 2(3):228-235

Tse LH, Wong YH. GPCRs in Autocrine and Paracrine Regulations. Front Endocrinol (Lausanne). 10:428

van de Willige D, Hummel JJ, Alkemade C, Kahn OI, Au FK, Qi RZ, Dogterom M, Koenderink GH, Hoogenraad CC, Akhmanova A. Cytolinker Gas2L1 regulates axon morphology through microtubule-modulated actin stabilization. EMBO Rep. 20(11):e47732

Wang HY, Guo LX, Hu WH, Peng ZT, Wang C, Chen ZC, Liu EYL, Dong TTX, Wang TJ, Tsim KWK. Polysaccharide From Tuberous Roots of Ophiopogon japonicus Regulates Gut Microbiota and Its Metabolites During Alleviation of High-fat Diet-induced Type-2 Diabetes in Mice. J Funct Foods. 63:103593

Wang T, Yan B, Lou L, Lin X, Yu T, Wu S, Lu Q, Liu W, Huang Z, Zhang M, Zhang W, Wen Z. Nlrc3-like is required for microglia maintenance in zebrafish. J Genet Genomics. 46(6):291-299

Xu ML, Luk WKW, Liu EYL, Kong XP, Wu QY, Xia YJ, Dong TTX, Tsim KWK. Differentiation of erythroblast requires the dimeric form of acetylcholinesterase: Interference with erythropoietin receptor. Chem.-Biol. Interact. 308:317-322

Xu ML, Zheng ZY, Xia YJ, Liu EY, Chan SK, Hu WH, Duan R, Dong TT, Zhan CS, Shang XH, Tsim KW. Shexiang Baoxin Pill, a formulated Chinese herbal mixture, induces neuronal differentiation of PC12 cells: a signaling triggered by activation of protein kinase A. Front Pharmacol. 10:1130

Zhou X, Chen Y, Mok KY, Kwok TCY, Mok VCT, Guo Q, Ip FC, Chen Y, Mullapudi N; Alzheimer’s Disease Neuroimaging Initiative, Giusti-Rodríguez P, Sullivan PF, Hardy J, Fu AKY, Li Y, Ip NY. Non-coding variability at the APOE locus contributes to the Alzheimer's risk. Nat Commun. 10(1):3310